Tips | Divinity Original Sin 2 Wiki

First timers should pick a default class and pick an origin story.
The Pet Pal talent is a very powerful talent that gives you a lot of additional information, options, and xp.
If you can, try to complete all quests. Lacking behind in levels will be punished even on the easiest difficulty.
You can fast travel to waypoints at any point throughout the game! check the buttons around your minimap!
Talk to everybody!
Get a bedroll as soon as possible! Healing outside the fights can be costly in the first part of the game. Clicking on a bed heals every character almost instantly.
Invest in Persuasion and let that party member do the talking to other NPCs.
Invest points in Lucky Charm and let that Character search all the containers.
Hit F5 to quick save your game frequently.
You should invest a few points in Telekinesis skill.
One of your characters should have points in Leadership.
Most utility spells (like Teleportation) don't need to scale, meaning having only one point in their respective school gives you access to an array of powerful abilities needed in a lot of different situations throughout the game.
You can completely respec all your party members when you reach Act 2.
Keep your Gear up to date, especially on harder difficulties. It's completely okay spending gold on Vendors to get better gear.